Smoked Turkey Grilled Cheese Sandwich

Featured in: Weeknight Dinners

This classic American sandwich combines smoked turkey breast with sharp cheddar cheese and a homemade cranberry-Dijon spread, all grilled to golden perfection on hearty bread. The sweet-savory flavor profile makes it ideal for lunch or a quick dinner.

Preparation takes just 10 minutes, with cooking completed in 8 minutes. Simply butter your bread, assemble with turkey, cheese, and cranberry spread, then grill until the cheese melts and bread turns golden brown.

Customize with Swiss or Gruyère cheese, add fresh greens like spinach or arugula, or swap in smoked Gouda for deeper flavor. Serves two and pairs wonderfully with salad or sweet potato fries.

Updated on Sun, 18 Jan 2026 15:38:00 GMT
Smoked Turkey Grilled Cheese sandwich with melted sharp cheddar and cranberry spread on golden toasted sourdough.  Save to Pinterest
Smoked Turkey Grilled Cheese sandwich with melted sharp cheddar and cranberry spread on golden toasted sourdough. | chromespoon.com

The skillet was already hot when I realized I had leftover turkey and a jar of cranberry sauce sitting in the fridge from last week. I wasn't planning on anything fancy, just something quick before heading back out, but the smell of butter hitting that pan made me slow down. Sometimes the best meals aren't the ones you plan. They're the ones that happen because you're hungry and a little bit curious. That's how this sandwich became my go-to whenever I need comfort without the fuss.

I made this for my neighbor once after she helped me carry groceries up three flights of stairs. She took one bite and asked if I'd been holding out on her. We ended up sitting on my kitchen counter, feet dangling, splitting the second sandwich and talking about nothing important. It's funny how a simple grilled cheese can turn into an afternoon you remember. She still texts me whenever she makes it now, usually with a photo and way too many exclamation points.

Ingredients

  • Hearty sandwich bread: Sourdough holds up to the heat and gives you those crispy edges, while whole wheat adds a nutty flavor that plays well with the turkey.
  • Smoked turkey breast: The smokiness is key here, it cuts through the richness of the cheese and makes the whole sandwich taste more complex than it actually is.
  • Sharp cheddar cheese: Don't go mild on this one, the sharpness balances the sweetness of the cranberry and keeps things from getting too sugary.
  • Cranberry sauce: Whole berry gives you little bursts of texture, but jellied works just fine if that's what you have.
  • Dijon mustard: Just a teaspoon adds enough tang to wake up the cranberry without overpowering it.
  • Unsalted butter: Softened butter spreads easier and gives you that even golden crust without tearing the bread.

Instructions

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Mix the cranberry spread:
Stir the cranberry sauce and Dijon mustard together in a small bowl until they're fully combined. This is where the magic starts, that sweet and tangy balance that makes the whole sandwich sing.
Butter the bread:
Lay out your bread slices and spread a thin layer of softened butter on one side of each. The buttered side goes down in the pan, so you're building from the outside in.
Spread the cranberry mixture:
On the unbuttered side of two slices, spread the cranberry mixture evenly, edge to edge. Don't be shy, you want that flavor in every bite.
Layer the turkey and cheese:
Pile the smoked turkey on top of the cranberry spread, then add the cheddar cheese. If you're using sliced cheese, overlap the pieces so you get full coverage.
Close the sandwiches:
Top each sandwich with the remaining bread slices, buttered side facing out. Press down gently so everything sticks together.
Heat the skillet:
Set a large skillet or griddle over medium heat and let it warm up for a minute or two. You want it hot enough to toast the bread but not so hot that it burns before the cheese melts.
Grill the sandwiches:
Place the sandwiches in the skillet and cook for 3 to 4 minutes per side, pressing gently with a spatula. You'll know it's ready to flip when the bottom is golden brown and crispy.
Rest and serve:
Remove the sandwiches from the pan and let them rest for a minute before slicing. This gives the cheese a chance to set just a little, so it doesn't all ooze out when you cut into it.
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A close-up view of Smoked Turkey Grilled Cheese showing melted cheese pull from the layered turkey and tangy cranberry sauce.  Save to Pinterest
A close-up view of Smoked Turkey Grilled Cheese showing melted cheese pull from the layered turkey and tangy cranberry sauce. | chromespoon.com

There was a rainy Tuesday last fall when I made this three times in one day. Once for lunch, once because my brother stopped by unexpectedly, and once more late at night because I couldn't stop thinking about it. By the third round, I had the timing down so perfectly that the cheese melted just as the bread hit that deep golden color. It's the kind of recipe that gets better the more you make it, not because it changes, but because you start to know it by heart.

Swaps and Variations

Swiss or Gruyère work beautifully if you want something a little milder and nuttier than cheddar. I tried smoked Gouda once and it added this deep, almost bacon-like richness that made the whole thing feel more indulgent. If you want to lighten it up, toss in a handful of baby spinach or arugula before you close the sandwich, the greens wilt just enough to add freshness without getting soggy. You could also swap the turkey for leftover rotisserie chicken or even thick-cut deli ham if that's what you have on hand.

Serving Suggestions

This sandwich is filling enough to stand on its own, but I like to serve it with a simple side salad dressed in lemon vinaigrette or a handful of sweet potato fries. Sometimes I'll cut it into quarters and serve it as an appetizer when people come over, it disappears faster than I expect every single time. A bowl of tomato soup on the side turns this into the ultimate cozy meal, especially when it's cold outside and you just want something warm and satisfying.

Storage and Reheating

Honestly, this sandwich is best eaten right away while the cheese is still gooey and the bread is crispy. If you do have leftovers, wrap them tightly in foil and store them in the fridge for up to a day. To reheat, skip the microwave and use a skillet over medium-low heat, covered, so the cheese melts again without drying out the bread. It won't be quite as perfect as fresh, but it's still pretty darn good.

  • Use a lid or another pan on top while reheating to trap the heat and melt the cheese faster.
  • If the bread gets too dark before the cheese melts, lower the heat and give it more time.
  • You can prep the cranberry spread ahead and keep it in the fridge for up to a week.
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Open-faced Smoked Turkey Grilled Cheese served with a side salad, highlighting the savory smoked turkey and sharp cheddar. Save to Pinterest
Open-faced Smoked Turkey Grilled Cheese served with a side salad, highlighting the savory smoked turkey and sharp cheddar. | chromespoon.com

This sandwich has gotten me through busy afternoons, lazy Sundays, and more than a few moments when I just needed something reliable and delicious. I hope it does the same for you.

Recipe FAQs

Can I prepare the cranberry spread ahead of time?

Yes, the cranberry-Dijon spread can be mixed and stored in an airtight container in the refrigerator for up to 3 days. This makes assembly even faster on busy days.

What bread works best for this sandwich?

Hearty breads like sourdough or whole wheat hold up best to the grilling process and provide excellent structure. Avoid thin breads that may tear or become soggy.

How do I prevent the bread from burning while melting the cheese?

Use medium heat and cook for 3-4 minutes per side, pressing gently. Medium heat ensures the cheese melts evenly before the bread over-browns. You can also reduce heat if browning too quickly.

What cheese alternatives work well in this sandwich?

Swiss cheese provides a milder flavor, Gruyère adds nuttiness, and smoked Gouda brings extra depth. All melt beautifully and complement the smoked turkey and cranberry spread.

Can I make this sandwich vegetarian?

You can omit the turkey and add roasted vegetables like bell peppers, mushrooms, or caramelized onions for a vegetarian version that maintains the sweet-savory balance.

Is this sandwich suitable for meal prep?

The spread and components can be prepped ahead, but assemble and cook just before serving for the best texture and melted cheese quality. Fresh bread and butter are essential for optimal results.

Smoked Turkey Grilled Cheese Sandwich

Smoked turkey, sharp cheddar, and cranberry spread melted on golden toasted bread for the ultimate comfort sandwich.

Prep time
10 minutes
Cook time
8 minutes
Overall time
18 minutes
Recipe by Marissa Cook


Skill level Easy

Cuisine American

Portion size 2 Portions

Dietary info None specified

What You'll Need

Sandwich

01 4 slices hearty sandwich bread, sourdough or whole wheat
02 4 oz smoked turkey breast, thinly sliced
03 4 oz sharp cheddar cheese, sliced or shredded

Cranberry Spread

01 3 tablespoons cranberry sauce, whole berry or jellied
02 1 teaspoon Dijon mustard

For Grilling

01 2 tablespoons unsalted butter, softened

Directions

Step 01

Prepare Cranberry Spread: In a small bowl, combine cranberry sauce and Dijon mustard, mixing until well blended.

Step 02

Butter the Bread: Lay out bread slices and spread a thin layer of butter on one side of each slice. Place buttered sides down on work surface.

Step 03

Assemble First Layer: Spread cranberry mixture evenly on two bread slices on their unbuttered sides.

Step 04

Add Protein and Cheese: Layer smoked turkey and cheddar cheese on top of the cranberry spread on both bread slices.

Step 05

Complete Sandwiches: Top each with remaining bread slices, buttered side facing outward.

Step 06

Preheat Cooking Surface: Heat a large skillet or griddle over medium heat.

Step 07

Cook Sandwiches: Place sandwiches in the skillet and cook for 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is melted.

Step 08

Rest and Serve: Remove from pan, let rest for 1 minute, then slice diagonally and serve warm.

Needed equipment

  • Skillet or griddle
  • Spatula
  • Small mixing bowl
  • Bread knife

Allergy Notes

Double-check your ingredients for allergens and always talk to your doctor if you're not sure.
  • Contains gluten from bread
  • Contains dairy including butter and cheese
  • Contains poultry from turkey
  • May contain mustard

Nutrition details (per portion)

Use these nutrition facts for reference—they don't replace advice from your doctor.
  • Energy (kcal): 420
  • Fat content: 20 grams
  • Carbohydrates: 36 grams
  • Proteins: 24 grams